Answer by Tonny for Denying user permissions for C Drive where Windows is...
You can't do that and still have the user be able to use the computer. Every user needs a minimum of read access to large parts of Windows itself and Full Control to certain portions of his own...
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I have added another user profile to my PC and have removed their access to the D drive through properties > security > edit and removing other users permissions (picture below for context)....
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